Titanium Dioxide in Foods Linked to Gut Inflammation, Etc.

July 5, 2018

"Food-grade TiO2 impairs intestinal and systemic immune homeostasis, initiates preneoplastic lesions and promotes aberrant crypt development in the rat colon…There are growing concerns that daily oral TiO2-NP intake is associated with an increased risk of chronic intestinal inflammation and carcinogenesis. In rats orally exposed for one week to E171 at human relevant levels, titanium was detected in the immune cells of Peyer's patches (PP)...a 100-day E171 treatment promoted colon microinflammation and initiated preneoplastic lesions while also fostering the growth of aberrant crypt foci in a chemically induced carcinogenesis model…The TiO2 food additive, referred to as E171 in the European Union (EU), is commonly used as a whitening and brightening agent in confectionary (candies and chewing gum), white sauces and icing…TiO2-NPs have been easily isolated from food products such as chewing gum…In humans, TiO2 particles of dietary origin have been found in the PP of patients suffering from inflammatory bowel disease (IBD)…including infants, and potent inflammasome activation has been reported in vitro using TiO2-NPs. These studies point to possible contributions to chronic inflammatory processes in the gut if TiO2 particles accumulate in the cells of the PP through chronic dietary exposure…Food-grade TiO2 particles initiate and promote preneoplastic lesion formation in the colon and induce mucosal low-grade inflammation..."
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