The "aloes" of the Bible are called "lign aloes" (which means "wood aloes"):
Numbers 24:6 As the valleys are they spread forth, as gardens by the river's side, as the trees of lign aloes which the LORD hath planted, and as cedar trees beside the waters.
They are therefore "trees," which produce a powerful aroma:
Psalms 45:8 All thy garments smell of myrrh, and aloes, and cassia...
(See also Proverbs 7:17, Song of Solomon 4:14, etc.)
It is therefore obvious that these O.T. aloes have nothing to do with what is known as the Aloe vera plant today. Also, there is no clear proof that these Biblical aloes were ever used internally.
There is therefore no Biblical sanction for the use of Aloe vera, and this means we must depend upon research outside the Scriptures in validating its benefits.
Aloe vera does have some helpful benefits when used externally. Some have found it useful to rub on swollen areas, where there is water retention. It is anti-inflammatory, and beneficial for burns and abrasions. It has reportedly been used by women for cosmetic reasons for centuries. Some studies report that it is a good mouthwash, that helps fight plaque on the teeth.
However, when used internally, there is quite a bit of controversy. I would personally avoid the use of Aloe vera internally, especially since the Bible is silent about this plant. (Some argue that the aloes used by Nicodemus for the burial of the Lord Jesus refer to aloe vera, but there is no evidence that these aloes are any different than the wood aloes of the O.T. Also, these aloes are not being used internally as food, drink or medicine).
Almost anything "natural" that does not outright kill a person instantly will be less toxic than the "side effects" of most pharmaceutical drugs! However, the following studies raise some serious red flags in the use of Aloe vera internally.
The first study shows that Aloe vera can irritate the intestines and may even promote cancer:
“…results indicate that Aloe vera whole-leaf extract is an intestinal irritant in F344/N rats and B6C3F1 mice and a carcinogen of the large intestine in F344/N rats…Because rodents do not usually develop spontaneous neoplasms of the colon, carcinogen induction of neoplasms in rodent colons has been used as a model for human colon cancer…”
(Toxicol Sci. 2013 Jan)
Other studies reveal that Aloe vera reduces fertility:
"Antifertility Activity of Ethanolic and Aqueous Extracts of Aloe Vera Mill on female wistar rats...antifertility activity in proven fertile female Wistar Rats…”
(Sunil Kumar Shah et al /J. Pharm. Sci. & Res. Vol. 8(9), 2016, 952-957)
“Aloe vera decreases motility and viability of sperms, finds research...”
“Aloe vera toxic effects…The testes weight, serum testosterone, as well as sperm count and fertility of the AVG treated groups were significantly reduced when compared to the control…"
(Iran J Basic Med Sci. 2015 Oct)
Lowering testosterone is not a good plan for any man!
It should be mentioned that Aloe vera does appear to have antioxidants. Therefore, it may increase fertility in men exposed to the damaging effects of X-rays, BPA, etc. See:
“Protective role of Aloe vera against X-ray induced testicular dysfunction…”
“Protective Effect of Aloe vera Extract against Bisphenol A Induced Testicular Toxicity in Wistar Rats…”
However, there are other, Biblical, more powerful substances that will achieve the same, protective results.
Aloe vera also contains large amounts of lupeol. You may begin hearing more about this in the future. Lupeol has anticancer properties. However, it has also been found to reduce fertility when given orally to male rats.
Furthermore, lupeol, even in small amounts, has been found to halt the final, necessary movement of male seed, hindering fertility of the egg:
"Sperm swim upstream in the reproductive track toward the egg using their tail, which normally moves with a steady, rhythmic motion. However, once sperm reach the egg and its protective cluster of cells, their tails switch to a whiplike motion, a power kick that gets the sperm through the scrum and into the egg…lupeol…lupeol blocked progesterone binding to ADHD2, preventing sperm's power kick…”
(Science Daily, May 5, 2017)
This appears to argue that women who ingest enough lupeol could create an internal environment that makes it impossible for seed to fertilize the egg.
There are personal testimonies of some who found that Aloe vera lowered their testosterone. Others have reported stomach issues.
I know that Big Pharma, etc. will often fund studies that demean anything natural, that may compete with drug sales. On the other hand, all that is "natural" is not good for food, or good for every purpose. Where the Creator has not spoken in the Bible, we must tread even more carefully. I would therefore avoid using Aloe vera internally.